Long-term effects of proton pump inhibitors

Sethu Babu
2015 Journal of Medical and Scientific Research  
This review summarizes the literature regarding long-term adverse effects of proton pump inhibitors (PPIs). There is widespread use of PPIs for a number of indications both in the inpatient and outpatient settings. While PPIs are generally considered safe and well tolerated, more serious adverse events have been reported. The risk of pneumonia was increased 27-39% in short-term use of PPIs in three meta-analyses. The use of PPIs is associated with Clostridium difficile infection (CDI) and
more » ... ion (CDI) and appears to be dose related. Fractures and the impaired magnesium absorption associated with the use of PPIs have led the FDA to issue a warning regarding their use. Thrombocytopenia, iron deficiency, vitamin B 12 deficiency, rhabdomyolysis and acute interstitial nephritis (AIN) have also been reported with the use of PPIs. Even though these adverse effects occur in small percentage of people, their impact should not be underestimated. PPIs are widely used and even a rare adverse effect may result in a large number of people being affected. Practitioners need to be vigilant about such adverse effects and counsel patients accordingly and use PPIs only when indicated. citation: Sethu Babu. Long-term effects of proton pump inhibitors. J Med Sci Res. 2015; 3(2):94-100. DOI: http://dx.doi.
doi:10.17727/jmsr.2015/3-019 fatcat:tjly5xsatzcvpcetehgbke37a4