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Journal of Medical and Scientific Research
This review summarizes the literature regarding long-term adverse effects of proton pump inhibitors (PPIs). There is widespread use of PPIs for a number of indications both in the inpatient and outpatient settings. While PPIs are generally considered safe and well tolerated, more serious adverse events have been reported. The risk of pneumonia was increased 27-39% in short-term use of PPIs in three meta-analyses. The use of PPIs is associated with Clostridium difficile infection (CDI) anddoi:10.17727/jmsr.2015/3-019 fatcat:tjly5xsatzcvpcetehgbke37a4