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Objective: Stressful life events experienced during childhood and as an adult negatively impact mental and physical health over the life span. This study examined polymorphisms from 2 hypothalamicpituitary-adrenal axis-related genes previously associated with posttraumatic stress disorder-FKBP5 and CRHR1-as moderators of the impact of child abuse and adult stress on physical health. Method: A national, community-based subsample of non-Hispanic European American respondents (n ϭ 527) from adoi:10.1037/a0033968 pmid:24099078 fatcat:ypwenk25hzbxbkeyuilonhruje