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The experience of social stress during adolescence is associated with higher vulnerability to drug use. Increases in the acquisition of cocaine self-administration, in the escalation of cocaine-seeking behavior, and in the conditioned rewarding effects of cocaine have been observed in rodents exposed to repeated social defeat (RSD). In addition, prolonged or severe stress induces a proinflammatory state with microglial activation and increased cytokine production. The aim of the present workdoi:10.1371/journal.pone.0206421 pmid:30365534 pmcid:PMC6203396 fatcat:eyxjjbgyeraubaoftbvkydpc2y