SDS-induced multi-stage unfolding of a small globular protein through different denatured states revealed by single-molecule fluorescence

Georg Krainer, Andreas Hartmann, Vadim Bogatyr, Janni Nielsen, Michael Schlierf, Daniel Otzen
2020 Chemical Science  
Ionic surfactants such as sodium dodecyl sulfate (SDS) unfold proteins in a much more diverse yet effective way than chemical denaturants such as guanidium chloride (GdmCl). But how these unfolding...
doi:10.1039/d0sc02100h pmid:34123163 pmcid:PMC8163379 fatcat:ag3qiopa7bgt5ltzf5fr5zqxrq