Dental Development and Anomalies in Cleft Lip and Palate [chapter]

Elaine Li Yen Tan, Mimi Yow
2019 Current Treatment of Cleft Lip and Palate [Working Title]  
Cleft lip and/or palate is a birth defect with heterogeneous clinical presentations. Prevalence and cleft-types differ by gender, ethnic groups and geographic locations. Published literature indicates high frequencies of cleft-associated dental anomalies, commonly variations in tooth-number, shape and size. Delayed dental development is also reported with catch-up growth at a later age. In the unilateral cleft phenotype, delayed development can occur on the cleft-side of the maxilla. Dental
more » ... maxilla. Dental anomalies present frequently in the spectrum of cleft defects. Heterogeneity of defects is wide-ranging and may represent different aetiological origins of cleft phenotypes and sub-types due to: genetic mutations with altered ectomesenchymal growth; iatrogenesis from disrupted blood supply during early postnatal surgery; and maldevelopment or mistimed development. Orofacial clefting and odontogenesis may share critical pathways.
doi:10.5772/intechopen.88310 fatcat:w5w4om5kbbabvp4lddgng72ph4