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Objective: To determine the toxicity of Sapium ellipticum (S. ellipticum) ethanol leaf extract in animal model. Methods: Three groups (I, II and III, n = 10) of Wistar rats were respectively given 0.5 mL corn oil, 400 and 800 mg/kg BW of S. ellipticum extract, twice daily, for a period of 14 days. Lethal dose (LD 50 ) was determined and morbidity was assessed via repeated dose administration of the extract. Results: S. ellipticum at the doses employed did not cause any significant changes indoi:10.12980/jclm.5.2017j7-80 fatcat:zpo44uz5izawhi3zoiaj75vire