A novel approach to synthesis of flibanserin

Pingili Krishna Reddy, K. Mukkanti, Dodda Mohan Rao
2016 International Journal of Current Research in Chemistry and Pharmaceutical Sciences  
The 1,3-dihydro-1-(2-bromoethyl)-3-isopropenyl-2H-benzimidazol-2-one was used as a starting material for making of the title compound. This compound treated with piperizine in the presence of TBAB as a catalyst which is treated with m-trifluoromethyl bromobenzene, in the presence of base and palladium acetate than followed by passing HCl gas to produced corresponding title compound in good yield with high purity. The structures of all the synthesized compounds were confirmed by IR, 1 H NMR, C
more » ... by IR, 1 H NMR, C 13 NMR and Mass Spectral data.
doi:10.22192/ijcrcps.2016.03.12.011 fatcat:me4xpa5ggzdv7lflq4pdiyoqla