Valproate (VPA)-Associated Hepatotoxicity

J Gordon Millichap
1993 Pediatric Neurology Briefs  
The metabolic pattern of VPA in 170 epileptic patients without symptoms or signs of hepatic side effects was compared to that in 11 patients with early symptoms and signs of hepatotoxicity and in 5 children with fulminant liver failure. A cohort of 470 patients in whom VPA serum metabolites had been measured were examined at several pediatric epilepsy clinics between 1986 and 1991 and results were evaluated at the . In the reference group, infants receiving VPA monotherapy and comedication with
more » ... other AEDs showed lower concentrations of the potential hepatotoxin 4-ene-VPA than did older children. Three of 4
doi:10.15844/pedneurbriefs-7-5-12 fatcat:57s5v7vbk5bfjmnhmem64pfdoy