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Cyclin-dependent kinase-5 (CDK5) and p35/p25 activators, interacting with the exocytotic machinery (e.g. munc18-1 and syntaxin-1A), play critical roles in neurosecretion. The basal status of CDK5/p35/p25 and the effect of psychotropic drugs (detected in blood/urine samples) were investigated in post-mortem prefrontal cortex (PFC)/Brodmann's area 9 of schizophrenia (SZ) and major depression (MD) subjects. In SZ (all subjects, n=24), CDK5 and p35, but not p25, were reduced (x28 to x58 %) compareddoi:10.1017/s1461145712000879 pmid:22964075 fatcat:2yes2dcuvnghlozcmgbv34hxta