Osteoarthritis (OA) is most prevalent chronic rheumatic disease, a leading cause of pain and disability in most countries. The comprehensive use of naturopathy including hot mud and mustard are common. Mustard application lacks scientific evidence while mud is established for treatment of OA. Hence present study aims to evaluate and compare the effect of hot mud and mustard applications to knee in patients with OA. Material and methodology: Sixty subjects were randomly assigned to either group

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... (hot mud application) or group 2 (mustard application). Subjects received interventions along with naturopathy treatments for ten days with assessments at baseline and post intervention. Assessment tools were Visual Analogue Scale (VAS), Western Ontario and McMaster Universities Secondary Osteoarthritis index (WOMAC), Measurement of range of motion knee by goniometry, and Short form-36 (SF-36). Results: The results showed significant difference in VAS in both groups. Group 2 showed significant reduction in Womac. Good improvement was seen in group 2 in right extension, left extension, physical functioning, social well-being, general physical health, compared to group 1. Rest of the variables in both groups had similar effects since there was not much significant change in both. The group 1 showed significant difference in pain (31.00+_67.42), when compared to group 2 (32.67+_72.42). Conclusion: The study result suggests that both hot mud application and mustard application could be considered effective in patients with OA while mustard application is more effective than hot mud application