Benzothiazole Thioflavin T improves obesity-related symptoms in mice

Fatemeh Jalalvand
2016 Periodicum biologorum  
and Purposes: In order to counteract the obesity epidemics, novel therapeutics are needed. Thioflavin T (ThT) is a benzothiazole used as an amyloid probe and has other properties such as anti-aging and antihyperglycemic effects. The current study aimed at investigating its effect on obesity. Materials and Methods: A mouse model of obesity was generated by feeding male NMRI mice with a high fat diet (HFD) for 8 weeks. After this period, mice diet was switched to normal rodent diet, and ThT was
more » ... diet, and ThT was orally administered with a 12 mg/Kg dose. The treatment effect was assessed on biochemical parameters, adipokines (adiponectin and leptin), total antioxidant capacity and TNF-a. Histological investigation was made on samples taken from adipose tissue and liver.
doi:10.18054/pb.2016.118.2.3592 fatcat:7q72twjsanfgrawtyaqjsojvtm