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Cutaneous B-Cell lymphoma can be associated with clinically significant nail alterations, the presentation of which can be unusual and misleading. To date, only a few reports have demonstrated direct specific tumor infiltration of the nail bed with lymphoma, while there is much less information about infiltration of nail bed with diffuse large B-cell lymphoma. Case Presentation: We describe the case of a 74 years old man presenting with nail bed ulceration who developed clinically significantdoi:10.5812/rro.2(1)2015.797 fatcat:psf6h56dargrlfthxzev5an75y