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Described herein is the development of a facile and efficient methodology for the synthesis of novel turmerone motif-fused 3,3 -pyrrolidinyl-dispirooxindoles 3-5 via a multicomponent 1,3-dipolar cycloaddition of dienones 2 with azomethine ylides (thermally generated in situfrom isatins and proline or thioproline or sarcosine). Products bearing four or three consecutive stereocenters consist of two oxindole moieties and a pyrrolidinyl core, including vicinal spiroquaternary stereocenters fuseddoi:10.3390/molecules22040645 pmid:28420177 fatcat:zvwwts2nxfcu7dwdbhsafzp2rm