Alanine Amino Transferase (ALT) Among Blood Donors Visiting King Abdulaziz Medical City Blood Donor Center

Salem Alshimemeri, Mohammed Alshareef, Mohammed Sambas, Abdulrahman Alshareef, Waleed Tamimi
International Journal of Academic Scientific Research   unpublished
Purpose: to determine Alanine Amino Transferase (ALT) level among blood donors visiting King Abdulaziz Medical City blood donor center.Patients and methods: This is a cross-sectional study where 434 blood samples that were serologically negative of Hepatitis B, Hepatitis C, HIV, HTLV, and Syphilis were taken from 434 seemingly healthy blood donors and were tested for ALT level.Results: The mean age of the donors was 30.1 + 8.6 years. The mean weight was 84.1 + 16.6 kg. The mean Hb level was
more » ... an Hb level was 15.54 + 1.24 g/dl. The mean ALT level was 32.76 + 23.24 U/L. The median ALT level was 26.00 and the 95th percentile was 69. 25 while the 5th percentile was 12.00. Out of the 434 donors, 51 (11.8%) had an ALT level higher than 55 U/L which is normal upper limit at our hospital's lab. The mean weight for donors with normal ALT was significantly lower than those with ALT >55 U/L (83.4 + 16.8 vs 89.7 + 14.2 U/L respectively, and p-value = 0.01).Conclusion: The study has found an association between weight and ALT level. We recommend reviewing the normal range of ALT. Also, we recommend screening overweight people for subclinical liver disease specifically non-alcoholic fatty liver disease NAFLD.