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MD; J-RHYTHM Investigators Background: The Japanese Rhythm Management Trial for Atrial Fibrillation (J-RHYTHM) study showed rhythm control was associated with fewer changes in the assigned treatment strategy compared to rate control in atrial fibrillation (AF). The aim was to describe how antiarrhythmics (AAs) were altered in the rhythm control arm and whether altering AAs would impact long-term outcomes. Methods and Results: Of 390 enrolled patients, 23.5% altered their AAs (drug alterationdoi:10.1253/circj.cj-09-0643 pmid:20379004 fatcat:wbamqzfiyjc4djctotzax6lnuy