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Results. 159 patients who underwent 2-stage exchange for TKA PJI meeting MSIS criteria were identified. 116 patients (73%) remained infection-free after two years of observation. Neither of the major criteria [presence of sinus drainage (P = 0.6); >1 positive culture (P = 1.0)], nor any of the minor criteria (individually or in composite) reached statistically significant association with treatment outcome. Conclusion. Individual MSIS diagnostic criteria, which have prognostic utility in TKAdoi:10.1093/ofid/ofy210.322 fatcat:fvxfbhykbfhznpgfey5jcxlqlq