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Association of TNF-alpha with type-2 diabetic mechanical hyperalgesia in rats
To study the role of tumour necrosis factors-alpha (TNF-alpha) in mechanical hyperalgesia in type-2-diabetic rat, diabetic mechanical hyperalgesia model was established in female Wister rats by combining high-fat diet for 4 weeks and single intraperitoneal injection of streptozotocin (STZ, 30 mg/kg, serum glucose increased from 12.7 ± 0.44 mmol/L to 28.3 ± 0.59 mmol/L after STZ injection). Based on hyperalgesia symptoms, rats were divided into hyperalgesia group (HFDH) and non-hyperalgesiafatcat:r5tty6ksnbexxptcha7oj3jvpe