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The enzymatic catalysis of difficult chemical reactions often requires the utilization of mechanisms completely different from those used in the uncatalyzed reaction. The catalytic triad of the serine proteases is an illustrative example for the cooperation of functional groups to achieve the hydrolysis of a very stable peptide bond via a covalent intermediate. Ribozymes for this demanding reaction that use similar mechanisms have neither been discovered nor developed to date. Here, wedoi:10.1039/c2sc21588h fatcat:qc4nimb7ezc2vk3onxfnqyosei