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Genetic Variants of LRRK2 in Taiwanese Parkinson's Disease
2013
PLoS ONE
Genetic variants of leucine-rich repeat kinase 2 (LRRK2) were reported to alter the risk for Parkinson's disease (PD). However, the genetic spectrum of LRRK2 variants has not been clearly disclosed yet in Taiwanese population. Herein, we sequenced LRRK2 coding region in 70 Taiwanese early onset PD patients (age at onset ≤ 50), and found six amino acid-changing single nucleotide polymorphisms (SNPs, N551K, R1398H, R1628P, S1647T, G2385R and M2397T), one reported (R1441H) and 2 novel missense
doi:10.1371/journal.pone.0082001
pmid:24339985
pmcid:PMC3855417
fatcat:tpdikdpbc5eozakzilv2c4weou