Bayesian Emulation and History Matching of JUNE [article]

Ian Vernon, Jonathan Owen, Joseph Aylett-Bullock, Carolina Cuesta-Lazaro, Jonathan Frawley, Arnau Quera-Bofarull, Aidan Sedgewick, Difu Shi, Henry Truong, Mark Turner, Joseph Walker, Tristan Caulfield (+2 others)
2022 medRxiv   pre-print
We analyse JUNE: a detailed model of Covid-19 transmission with high spatial and demographic resolution, developed as part of the RAMP initiative. JUNE requires substantial computational resources to evaluate, making model calibration and general uncertainty analysis extremely challenging. We describe and employ the Uncertainty Quantification approaches of Bayes linear emulation and history matching, to mimic the JUNE model and to perform a global parameter search, hence identifying regions of
more » ... arameter space that produce acceptable matches to observed data.
doi:10.1101/2022.02.21.22271249 fatcat:ebwi3qwecvdxxklwlkhmid4ucm