Crystal Structure of N,N'-(p-Chlorophenyl)thiourea

Manuel SORIANO-GARCÍA, Trujillo Gonzalo CHÁVEZ, Francisco Díaz CEDILLO, Ana Elizabeth Dominguez PÉREZ, Gerardo Aguirre HERNÁNDEZ
2001 Analytical Sciences  
As promising chelating agents for the treatment of lead and mercury poisoning in humans, 1 we are currently working on the synthesis of a new series of chelating agents, such as N,N′-(pchlorophenyl)thiourea (Fig. 1 ). In this paper, we present the crystal structure of (I). It is important to mention that there are a few structure reports exclusively concerning substitutedthiourea derivatives, which may be due to the difficulty in preparing crystals for X-ray diffraction studies. A solution of
more » ... chloroaniline (2.25 g, 17.6 mmol) in 5 mL of anhydrous THF was slowly added to p-chlorophenylisothiocyanate (3.0 g, 17.6 mmol) in 10 mL of anhydrous THF under a nitrogen atmosphere. The reaction mixture was stirred at 60˚C for 1 h. After removing the volatile materials in a vacuum, a white powder (3.8 g, yield of 94%) was purified with ethanol and recrystallized with acetone:hexane (1:1; v/v); m.p. 154 -
doi:10.2116/analsci.17.799 pmid:11707957 fatcat:atmjdbjxongthavluuorvhh5rq