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Interactions between the EGF receptor and DPP pathways establish distinct cell fates in the tracheal placodes
The formation of the tracheal network in Drosophila is driven by stereotyped migration of cells from the tracheal pits. No cell divisions take place during tracheal migration and the number of cells in each branch is fixed. This work examines the basis for the determination of tracheal branch fates, prior to the onset of migration. We show that the EGF receptor pathway is activated by localized processing of the ligand SPITZ in the tracheal placodes and is responsible for the capacity to formpmid:9409686 fatcat:xtvtvw3lm5b5nefxr5ejy7t72y