Over the last decades, Life Course Research (LCR), predominantly the domain of sociology, has been increa singly applied in health research, as Life Course Epi demiology (LCE). The latter is concerned with disease patterns over time, accumulation of exposures over time, critical time periods and patterns of risk. We argue that concepts from LCR and LCE could be widely applied in dermatology, in general, and, more precisely, in the study of chronic inflammatory skin diseases, e.g. atopic eczema

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... nd psoriasis. The life course approach can generally be applied in two different ways. It may be used in the more traditional manner, in which the disease and its pat terns over time are examined as the outcome vari able. Conversely, it can examine life course as the outcome variable, which is dependent on the disease course, the treatments administered, and other physical or psycho social environmental exposures. In dermatology, this se cond application of the LCR concepts is both promising and relevant because of the notable impact of chronic skin diseases on the patients' quality of life. In particular, we argue how LCR may be conducive to a better un derstanding of the concept of 'Cumulative Life Course Impairment', which is increasingly gaining acceptance. This approach helps identifying not only individuals at risk and particularly vulnerable patients but also criti cal periods for optimising interventions in order to avoid life course impairment. It also may facilitate more app ropriate treatment decisions in clinical practice.