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Yellow Fever Vaccine: Direct Challenge of Monkeys Given Graded Doses of 17D Vaccine
In rhesus monkeys a wide dosage range of 17D yellow fever (YF) vaccine extending to a level even below that recommended for vaccination of man elicited an immune response providing solid protection to challenge with virulent YF virus. Forty-three of 45 monkeys vaccinated with 10283 or greater weanling mouse mean lethal doses of 17D vaccine were resistant to challenge 20 weeks later with virulent Asibi strain YF virus. Monkeys given graded doses of lesser amounts of vaccine were progressivelydoi:10.1128/am.25.4.539-544.1973 fatcat:gc6c7ke2ibgw3fpbc73m6psvfy