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Aromatic side-chain flips orchestrate the conformational sampling of functional loops in Human Histone Deacetylase 8
2021
Chemical Science
Preserved Fulltext
Human histone deacetylase 8 (HDAC8) is a key hydrolase in gene regulation and an important drug-target. High-resolution structures of HDAC8 in complex with substrates or inhibitors are available, which have...
doi:10.1039/d1sc01929e
fatcat:2o7yzgjaxvcxxc2bx5aygvnvam