Meta-Analysis-based Examination regarding the Efficacy of Angiotensin II Receptor Blockers and Calcium Channel Blockers in Borderline Diabetes and Diabetes Patients

Junichi MUKAI, Hitoshi TADA, Masatomo MIURA, Kiminori MOHRI
2011 Yakugaku zasshi  
We performed a meta-analysis to assess antihypertensive eŠect, lipid metabolism, insulin resistance index, and body weight changes in patients with borderline diabetes and diabetes treated with angiotensin II receptor blockers (ARB) and dihydropyridine calcium channel blockers (CCB). Literatures for analysis were searched in MEDLINE, the Cochrane Library, and Japana Centra Revuo Medicina. Reports on randomized controlled trials in which the therapeutic results in borderline and diabetic
more » ... nd diabetic patients were compared between those treated with ARB and CCB were retrieved, and 16 reports met the objective of this study. The e‹cacy in the two drug treatment groups were divided into 8 outcomes and evaluated. The e‹cacy outcomes on handling continuous data were integrated using the weighted mean diŠerence, in which the random-eŠects model was selected for the statistical model. The statistical heterogeneity of each outcome was also tested. The systolic and diastolic blood pressures were signiˆcantly reduced in the CCB compared to the ARB treatment group. No signiˆcant diŠerences were noted between the two groups in the triglyceride or low-density lipoprotein cholesterol level or body weight changes. It was shown that the CCB was more eŠective than ARB for the improvement of systolic and diastolic blood pressures in patients with borderline diabetes and diabetes, while no signiˆcant diŠerences were noted in the e‹cacy other than the antihypertensive eŠect between ARB and CCB treatment groups. This study would provide information in selecting antihypertensive agents for borderline and diabetic patients.
doi:10.1248/yakushi.131.1213 pmid:21804326 fatcat:32ieaq3zdbbzjkixm2bnprxjom