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Current concepts on the pathogenesis of systemic amyloidosis
Nephrology, Dialysis and Transplantation
Amyloidosis is a pathological condition in which protein is deposited extracellularly in the form of insoluble fibrils that lead to organ dysfunction and death. Many different types of proteins are known to form amyloid and cause a heterogeneous array of clinical conditions. The unifying aspect of these conditions is the common structural entity resulting from the assembly of a primarily P-structure protein into 5-10 nm wide non-branching insoluble fibrils displaying the characteristic greendoi:10.1093/ndt/11.supp9.53 pmid:9050036 fatcat:zlmv2xgl7bbxpe3r3uj67kvx5y