GnRH analog treatment in children with congenital adrenal hyperplasia complicated by central precocious puberty

Ayla Guven, Ayse Nurcan Cebeci, Suna Hancili
2013 Endocrine Abstracts  
BACKGROUND and AIM In patients with congenital adrenal hyperplasia (CAH), final height may be compromised due to high levels of androgens. This condition is more prominent in patients incompatible with treatment or in undertreated patients. Increased adrenal androgen production causes an alteration in bone age with loss of growth potential. Moreover, central precocious puberty (CPP) might be seen in those patients as a result of stimulation of the hypothalamic-pituitary axis. Gonadotropin
more » ... ing hormone analogs (GnRHa) have been used effectively in treatment of CPP since many years. By consistent stimulation of gonadotrophic hormones, GnRHa provide inhibition of cyclic secretion of those hormones and prevent the progression of puberty. Our aim in this study was to investigate the effect of GnRHa treatment on growth in patients with CAH and CPP.
doi:10.1530/endoabs.32.p802 fatcat:nlm7errbl5ah7b4kkrgzlcwvsa