Photon pathlength determination based on spatially resolved diffuse reflectance

Henrik Nilsson, Marcus Larsson, Gert E. Nilsson, Tomas Strömberg
2002 Journal of Biomedical Optics  
A method for the prediction of the average photon pathlength in turbid media has been developed. The method is based on spatially resolved diffuse reflectance with discrete source detector distances up to 2 mm. Light reflectance was simulated using a Monte Carlo technique with a one-layer model utilizing a wide range of optical properties, relevant to human skin. At a source detector separation of 2 mm, the pathlength can vary sixfold due to differences in optical properties. By applying
more » ... By applying various preprocessing and prediction techniques, the pathlength can be predicted with a root-mean-square error of approximately 5%. Estimation of the photon pathlength can be used, e.g., to remove the influence of optical properties on laser Doppler flowmetry perfusion readings, which are almost linearly related to the average photon pathlength. © 2002 Society of Photo-Optical Instrumentation Engineers. Terms of Use: https://www.spiedigitallibrary.org/terms-of-use pathlength, +, KNN method using m 2 and m 3 values based on all nine fibers, ᭝, KNN method using R i values from fibers 3 and 7, ϫ, KNN method using m 1 , m 2 , and m 3 values based on all nine fibers, and ᮀ, MPR method using m 1 , m 2 , and m 3 values based on all nine fibers.
doi:10.1117/1.1482378 pmid:12175300 fatcat:gj3mvmf6d5bxrhbptnf2dw5jti