Complement-Fixing Antigens in Tissue Cultures of Avian Leucosis Viruses

D. Armstrong, M. Okuyan, R. J. Huebner
1964 Science  
Avian sarcoma and leucosis virus preparations grown in chick embryo tissue cultures contained complement-fixing antigens, which were demonstrated with the use of antiserums from hamsters carrying sarcomas induced by the Schmidt-Ruppin strain of avian sarcoma virus. The complement-fixing antigens shared by three different strains of avian leucosis and one strain of avian sarcoma viruses were largely "soluble" (having failed to sediment when centrifuged at 59,364g for 70 minutes). Sedimented
more » ... cles, presumably virus particles, contained the common sarcoma-leucosis antigen as well.
doi:10.1126/science.144.3626.1584 pmid:14169348 fatcat:qp2gbokk3res7olu7irogpufra