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We present a portable system for non-invasive, simultaneous sensing of molecular oxygen (O 2 ) and water vapor (H 2 O) in the human paranasal cavities. The system is based on high-resolution tunable diode laser spectroscopy (TDLAS) and digital wavelength modulation spectroscopy (dWMS). Since optical interference and non-ideal tuning of the diode lasers render signal processing complex, we focus on Fourier analysis of dWMS signals and procedures for removal of background signals. Clinical datadoi:10.1364/oe.17.010849 pmid:19550485 fatcat:cvf6qdloind73izhfc25vlkzl4