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Metabolic and transcriptomic profiles of glioblastoma invasion revealed by comparisons between patients and corresponding orthotopic xenografts in mice
2021
Acta Neuropathologica Communications
AbstractThe invasive behavior of glioblastoma, the most aggressive primary brain tumor, is considered highly relevant for tumor recurrence. However, the invasion zone is difficult to visualize by Magnetic Resonance Imaging (MRI) and is protected by the blood brain barrier, posing a particular challenge for treatment. We report biological features of invasive growth accompanying tumor progression and invasion based on associated metabolic and transcriptomic changes observed in patient derived
doi:10.1186/s40478-021-01232-4
pmid:34348785
pmcid:PMC8336020
fatcat:vufxxwz7jffehlk4eyrt2435ay