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8-cyclopentyl-3-(3-18F-fluoropropyl)-1-propylxanthine (18F-CPFPX) is a novel PET ligand for in vivo quantification of cerebral A1 adenosine receptors. The present study investigated the applicability of voxelwise graphical analysis to the generation of parametric images of the total volume of distribution (DVt) of 18F-CPFPX as a prerequisite for voxel-by-voxel statistical analysis. The benefit of spatial smoothing for reduction of noise-dependent negative bias in graphical analysis waspmid:16455624 fatcat:3myokm6jbra3zavfawhexsvjz4