18F-CPFPX PET: on the generation of parametric images and the effect of scan duration

Philipp T Meyer, David Elmenhorst, Andreas Matusch, Oliver Winz, Karl Zilles, Andreas Bauer
2006 Journal of Nuclear Medicine  
8-cyclopentyl-3-(3-18F-fluoropropyl)-1-propylxanthine (18F-CPFPX) is a novel PET ligand for in vivo quantification of cerebral A1 adenosine receptors. The present study investigated the applicability of voxelwise graphical analysis to the generation of parametric images of the total volume of distribution (DVt) of 18F-CPFPX as a prerequisite for voxel-by-voxel statistical analysis. The benefit of spatial smoothing for reduction of noise-dependent negative bias in graphical analysis was
more » ... Additionally, the effect of scan duration on the accuracy of analyses based on volumes of interest (VOIs) and individual voxels was explored.
pmid:16455624 fatcat:3myokm6jbra3zavfawhexsvjz4