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A 1-GΩ CMOS transimpedance amplifier (TIA) suitable for processing sub-nA-level currents in electrochemical biosensor signal-acquisition circuits is presented. Use of a twostage active transconductor provides resistive feedback in place of a large-area linear resistor. The TIA feedback loop is engineered to suppress output offset caused by DC input leakage currents of ±0.9 nA. A mechanism to tune the low-frequency cutoff of the TIA from 0.7 Hz to 500 Hz is implemented which permits operationdoi:10.1109/iscas.2014.6865056 dblp:conf/iscas/IbrahimL14 fatcat:ixrcq4eyszgv3okk6joaqc7aze