A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2020; you can also visit the original URL.
The file type is application/pdf
.
Mixtures of prion substrains in natural scrapie cases revealed by ovinised murine models
2020
Scientific Reports
Phenotypic variability in prion diseases, such as scrapie, is associated to the existence of prion strains, which are different pathogenic prion protein (PrPSc) conformations with distinct pathobiological properties. To faithfully study scrapie strain variability in natural sheep isolates, transgenic mice expressing sheep cellular prion protein (PrPC) are used. In this study, we used two of such models to bioassay 20 scrapie isolates from the Spain-France-Andorra transboundary territory.
doi:10.1038/s41598-020-61977-1
pmid:32193445
fatcat:e4x3lcbrhbbnfgwgjuas2g2dta