High-resolution photoacoustic vascular imaging in vivo using a large-aperture acoustic lens

Konstantin Maslov, Lihong V. Wang, Alexander A. Oraevsky, Lihong V. Wang
2005 Photons Plus Ultrasound: Imaging and Sensing 2005: The Sixth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics  
High-resolution photoacoustic vascular imaging in vivo using a large-aperture acoustic lens," Proc. SPIE 5697, Photons ABSTRACT Reflection-mode photoacoustic microscopy with dark-field laser pulse illumination and high frequency ultrasonic detection is used to non-invasively image blood vessels in the skin in vivo. Dark-field illumination minimizes the interference caused by strong photoacoustic signals from superficial structures. A high numerical-aperture acoustic lens provides high lateral
more » ... solution, 45-120 micrometers in this system while a broadband ultrasonic detection system provides high axial resolution, estimated to be ~15-20 micrometers. The optical illumination and ultrasonic detection are in a coaxial confocal configuration for optimal image quality. The system is capable of imaging optical-absorption contrast at up to 3 mm depth in biological tissue.
doi:10.1117/12.590558 fatcat:bf2jaytrsbfz5mvk74v7z66ftu