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Critical assessment of structure-based sequence alignment methods at distant relationships
2011
Briefings in Bioinformatics
Accurate sequence alignments are crucial for modelling and to provide an evolutionary picture of related proteins. It is well-known that alignments are hard to obtain during distant relationships. Three thousand and fifty-two alignments of 218 pairs of protein domain structural entries, with <40% sequence identity, belonging to different structural classes, of diverse domain sizes and length-rigid/variable domains were performed using 12 programs. Structural parameters such as root mean square
doi:10.1093/bib/bbq025
pmid:21422071
fatcat:6bdx4dzvbreefjtr4w5r7ash3u