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Inhibitors of Protein Methyltransferases and Demethylases
2017
Chemical Reviews
Post-translational modifications of histones by protein methyltransferases (PMTs) and histone demethylases (KDMs) play an important role in the regulation of gene expression and transcription and are implicated in cancer and many other diseases. Many of these enzymes also target various nonhistone proteins impacting numerous crucial biological pathways. Given their key biological functions and implications in human diseases, there has been a growing interest in assessing these enzymes as
doi:10.1021/acs.chemrev.6b00801
pmid:28338320
pmcid:PMC5610952
fatcat:ifwczoutfndpljmpeqkyw2tsxm