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hnRNP A1 regulates UV-induced NF-κB signalling through destabilization of cIAP1 mRNA
Cell Death and Differentiation
cIAP1 is an important member of the inhibitor of apoptosis family of proteins and is involved in the regulation of the NF-jBsignalling pathway downstream of the TNF receptor. We report here that UV irradiation leads to downregulation of cIAP1 expression because of enhanced cIAP1 mRNA destabilization. An AU-rich element located within the 3 0 untranslated region of cIAP1 mRNA is sufficient to mediate cIAP1 mRNA instability. Furthermore, we have identified hnRNP A1 as a cIAP1 3 0 UTR-bindingdoi:10.1038/cdd.2008.146 pmid:18846111 fatcat:pifot3gb2zc6reqzehqkb6pzju