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A versatile human intestinal organoid-derived epithelial monolayer model for the study of enteric pathogens
[article]
2020
bioRxiv
pre-print
Gastrointestinal infections cause significant morbidity and mortality worldwide. The complexity of human biology and limited insights into host-specific infection mechanisms are key barriers to current therapeutic development. Here, we demonstrate that two-dimensional epithelial monolayers derived from human intestinal organoids, combined with in vivo-like bacterial culturing conditions, provide significant advancements for the study of enteropathogens. Monolayers from the terminal ileum,
doi:10.1101/2020.11.24.397141
fatcat:pd2ruouminaivmj2oezyxhibey