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Use of Melatonin in Oxidative Stress Related Neonatal Diseases
Reactive oxygen species have a crucial role in the pathogenesis of perinatal diseases. Exposure to inflammation, infections, or high oxygen concentrations is frequent in preterm infants, who have high free iron levels that enhance toxic radical generation and diminish antioxidant defense. The peculiar susceptibility of newborns to oxidative stress supports the prophylactic use of melatonin in preventing or decreasing oxidative stress-mediated diseases. Melatonin, an effective directdoi:10.3390/antiox9060477 pmid:32498356 fatcat:vaepblostnhdtml5xvbsko7tai