Supplementations of chromium (Cr) have been shown to exert beneficial effects for the management of type-2 diabetes, as reflected by a decline in insulin response. Prevalence of chromium deficiency in patients with prediabetes is not well understood; the aim of this study was to evaluated the amount of this prevalence. Methods: In this cross-sectional descriptive study, were recruited 132 patients with prediabetes. Participants were randomly selected from those referred to the Shariati

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... Isfahan, Iran. Fasting venous blood samples were collected from participants to measure the levels of chromium, insulin, fasting blood sugar and 2-hour post load plasma glucose. Body mass index was calculated. Determination of Cr was carried out by atomic absorption spectrometry. Findings: Of 132 patients, 24 were excluded due to failure to complete the test. Among remained patients, 34 (31.5%) had chromium deficiency, and 74 (68.5%) had normal serum levels of chromium. A significant inverse relationship was found between chromium levels and age in normal group. Conclusion: Levels of chromium deficiency is relatively common in patients with prediabetes and it is necessary to eliminate chromium deficiency in screening patients for diabetes.