A Con Artist: Phenylphenoxybenzamide is not a Glycosyltransferase Inhibitor [article]

Gjalt G Wybenga, Wei-Shen Wu
2018 bioRxiv   pre-print
To combat bacterial resistance against antibiotics, glycosyltransferase inhibiting molecules, which block the synthesis of the pre-cursor of the bacterial cell wall, need to be discovered and developed. In this study, we demonstrate that phenylphenoxybenzamide, a salicylanilide, is not a glycosyltransferase inhibiting molecule, despite claims in literature to the contrary, and through our work show that glycosyltransferase construct choice and detergent choice are crucial parameters to consider
more » ... ameters to consider when designing glycosyltransferase assays that aim to discover and develop molecules that inhibit these types of enzymes.
doi:10.1101/292912 fatcat:lvmbyem6jje57g3ycahx2h5unm