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Structure-Guided Modeling and Binding Studies of GABAA Receptor Subunit Beta-3
International Journal of Computer Applications
The major inhibitory GABA systems are known to take part a vital role in epilepsy, associated with excessive neuronal circuitry excitation. This excitatory action reflects seizures which result from GABA inhibitory circuit dysfunction. GABA mediates its fast inhibition through GABA A receptors by activating it and then opens the chloride channels. This opening allows chloride ions to flow into the interior of the cell which inhibits the excitability. This inhibitory action devisesdoi:10.5120/9627-4275 fatcat:byevzt5exnfk3fyyqmxuvjizfm