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S -Nitrosothiol-Modified Dendrimers as Nitric Oxide Delivery Vehicles
The synthesis and characterization of two generation-4 polyamidoamine (PAMAM) dendrimers with S-nitrosothiol exteriors are reported. The hyperbranched macromolecules were modified with either N-acetyl-D,L-penicillamine (NAP) or N-acetyl-L-cysteine (NACys) and analyzed via 1H and 13C-NMR, UV absorption spectroscopy, MALDI-TOF mass spectrometry, and size exclusion chromatography. Treatment of the dendritic thiols with nitrite solutions yielded the corresponding S-nitrosothiol nitric oxide (NO)doi:10.17615/t1qm-e483 fatcat:thwacx2nuvfm7ghrd3qc7lw7gu