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Wave-front distortion compensation using direct system performance metric optimization is studied both theoretically and experimentally. It is shown how different requirements for wave-front control can be incorporated, and how information from different wave-front sensor types can be fused, within a generalized gradient descent optimization paradigm. In our experiments a very-large-scale integration (VLSI) system implementing a simultaneous perturbation stochastic approximation optimizationdoi:10.1364/josaa.17.001440 pmid:10935872 fatcat:bqcxhxpqyvhsbh34peoavss3qq