Mobility and transverse flow visualization using phase variance contrast with spectral domain optical coherence tomography

Jeff Fingler, Dan Schwartz, Changhuei Yang, Scott E. Fraser
2007 Optics Express  
Phase variance-based motion contrast is demonstrated using two phase analysis methods in a spectral domain optical coherence tomography system. Mobility contrast is demonstrated for an intensity matched Intralipid solution placed without flow within agarose wells. Vasculature oriented transversely to the imaging direction has been imaged for 3-4 dpf in vivo zebrafish using the phase variance contrast methods. 2D phase variance contrast images are demonstrated with imaging times only 25% higher
more » ... es only 25% higher than a Doppler flow image with comparable statistics. En face images created by integrating depth regions of 3D zebrafish intensity and phase variance contrast data demonstrate vasculature consistent with expected images.
doi:10.1364/oe.15.012636 pmid:19550532 fatcat:n5z77avxene6zodcisafgmmnfa