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The Human 20-kDa 5′-(CGG)n-3′-binding Protein Is Targeted to the Nucleus and Affects the Activity of theFMR1Promoter
2000
Journal of Biological Chemistry
Previous reports have described the human DNA CGG repeat-binding protein (CGGBP1 or p20), which binds specifically to nonmethylated, but not to methylated, 5-(CGG) n -3 repeats in the promoter of the fragile X mental retardation 1 (FMR1) gene. The results of transfection experiments into human HeLa cells using a p20green fluorescent protein fusion construct indicate that the p20 protein is targeted to the nucleus. By deletion analyses, a nuclear localization signal has been found between amino
doi:10.1074/jbc.275.9.6447
pmid:10692448
fatcat:nfit7hsbwvgivhxnnrmfwqijsi