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AMPK/HuR-Driven IL-20 Post-Transcriptional Regulation in Psoriatic Skin
2015
Journal of Investigative Dermatology
IL-20 is involved in the development of skin psoriasis. The molecular mechanisms underlying IL-20 overexpression in psoriatic epidermis remain to be elucidated. We showed that IL-20 was primarily upregulated in psoriatic skin at the post-transcriptional level. The RNA-binding protein HuR relocalized to the cytoplasm of keratinocytes (KCs) of psoriatic patients, suggesting that it stabilizes numerous transcripts, as observed in the human KC cell lines used to assess IL-20 mRNA. We characterized
doi:10.1038/jid.2015.282
pmid:26176762
fatcat:bnlk7bcwrfaypj3zf76kiw5l4a