PubChem BioAssay: 2014 update

Yanli Wang, Tugba Suzek, Jian Zhang, Jiyao Wang, Siqian He, Tiejun Cheng, Benjamin A. Shoemaker, Asta Gindulyte, Stephen H. Bryant
2013 Nucleic Acids Research  
PubChem's BioAssay database (http://pubchem. ncbi.nlm.nih.gov) is a public repository for archiving biological tests of small molecules generated through high-throughput screening experiments, medicinal chemistry studies, chemical biology research and drug discovery programs. In addition, the BioAssay database contains data from highthroughput RNA interference screening aimed at identifying critical genes responsible for a biological process or disease condition. The mission of PubChem is to
more » ... ve the community by providing free and easy access to all deposited data. To this end, PubChem BioAssay is integrated into the National Center for Biotechnology Information retrieval system, making them searchable by Entrez queries and cross-linked to other biomedical information archived at National Center for Biotechnology Information. Moreover, PubChem BioAssay provides web-based and programmatic tools allowing users to search, access and analyze bioassay test results and metadata. In this work, we provide an update for the PubChem BioAssay resource, such as information content growth, new developments supporting data integration and search, and the recently deployed PubChem Upload to streamline chemical structure and bioassay submissions.
doi:10.1093/nar/gkt978 pmid:24198245 pmcid:PMC3965008 fatcat:57wu2puoovaevlpqtrp5pjsq7e